To develop cellular, genomic and proteomic technologies for the diagnosis of socially-significant diseases in the Republic of Kazakhstan
In the Republic of Kazakhstan, the government pays special attention to the development of highly sensitive and accurate methods for diagnosis of various diseases. The Ministry of Health has approved a list of socially-significant diseases, such as malignant neoplasms, diabetes, a number of cardiovascular and infectious diseases, diseases of the nervous system, etc. (Decree № DSM-108/2020 from the Ministry of Health of the Republic of Kazakhstan from September 23, 2020). As part of this scientific and technical program, methods and technologies will be developed for the effective diagnosis of socially significant diseases using modern cellular, genomic, proteomic technologies and instrumental methods, such as next-generation sequencing (NGS), mass spectrometry, digital PCR, real-time PCR, CRISPR/Cas technology, DNA barcoding, etc. Within the framework of the Program, it is planned to develop methods for early diagnosis of orphan diseases, including phenylketonuria and Gaucher disease, diagnosis of Alport syndrome, MODY diabetes, ischemic stroke, colorectal cancer; as well as develop technologies and test systems for detection of a number of infectious diseases caused by pathogens of both bacterial (Borrelia burgdorferi, Borrelia miyamatoi, Acinetobacter baumannii) and viral origin (rotaviruses and adenoviruses). To ensure further production of domestic test systems, it is proposed to develop a technology for obtaining thermostable RNA and DNA dependent polymerases used in PCR test systems, and a high-precision DNA technology for the authentication of herbal medicine. These developments will not only improve the quality of medical care and quality of patient’s life in Kazakhstan, but will also increase its competitiveness at the international level, promoting the widespread use of modern diagnostic technologies in clinical practice and laboratory diagnostics.
Thus, in order to achieve progress in this relevant area, the main goal of our study was formulated and the expected results were determined.
Specialist in the field of genomics, proteomics and mass spectrometry, the author of more than 100 scientific papers, Hirsch index - 11 (Scopus). Studied in the master’s program “Bolashak” (USA, Montana State University, 2007-2009). Scholarship holder of the World Federation of Scientists (Switzerland, 2010). COmpleted internships in France (Institute Gustave-Roussy, 2011-2012), Russia (“Medical and Genetic center of N.P. Bochkov”, 2012).
Head of the Laboratory of Applied Genetics of the NCB
Head of the National Scientific Shared Laboratory of Biotechnology of the NCB
Leading Researcher at the National Scientific Shared Laboratory of Biotechnology of the NCB
Chief Researcher of the Laboratory of Proteomics and Mass Spectrometry of the NCB
Head of the Laboratory of Immunochemistry and Immunobiotechnology of the NCB
Head of the Laboratory of Molecular Biotechnology of the NCB
Head of the Laboratory of Immunology and Immunobiotechnology of the NCB branch in Almaty
Head of the Laboratory of Genetics and Biochemistry of Microorganisms of the NCB
Head of the Laboratory of Plant Genomics and Bioinformatics
To develop cellular, genomic and proteomic technologies for the diagnosis of socially-significant diseases in the Republic of Kazakhstan
In the Republic of Kazakhstan, the government pays special attention to the development of highly sensitive and accurate methods for diagnosis of various diseases. The Ministry of Health has approved a list of socially-significant diseases, such as malignant neoplasms, diabetes, a number of cardiovascular and infectious diseases, diseases of the nervous system, etc. (Decree № DSM-108/2020 from the Ministry of Health of the Republic of Kazakhstan from September 23, 2020). As part of this scientific and technical program, methods and technologies will be developed for the effective diagnosis of socially significant diseases using modern cellular, genomic, proteomic technologies and instrumental methods, such as next-generation sequencing (NGS), mass spectrometry, digital PCR, real-time PCR, CRISPR/Cas technology, DNA barcoding, etc. Within the framework of the Program, it is planned to develop methods for early diagnosis of orphan diseases, including phenylketonuria and Gaucher disease, diagnosis of Alport syndrome, MODY diabetes, ischemic stroke, colorectal cancer; as well as develop technologies and test systems for detection of a number of infectious diseases caused by pathogens of both bacterial (Borrelia burgdorferi, Borrelia miyamatoi, Acinetobacter baumannii) and viral origin (rotaviruses and adenoviruses). To ensure further production of domestic test systems, it is proposed to develop a technology for obtaining thermostable RNA and DNA dependent polymerases used in PCR test systems, and a high-precision DNA technology for the authentication of herbal medicine. These developments will not only improve the quality of medical care and quality of patient’s life in Kazakhstan, but will also increase its competitiveness at the international level, promoting the widespread use of modern diagnostic technologies in clinical practice and laboratory diagnostics.
Thus, in order to achieve progress in this relevant area, the main goal of our study was formulated and the expected results were determined.
Specialist in the field of genomics, proteomics and mass spectrometry, the author of more than 100 scientific papers, Hirsch index - 11 (Scopus). Studied in the master’s program “Bolashak” (USA, Montana State University, 2007-2009). Scholarship holder of the World Federation of Scientists (Switzerland, 2010). COmpleted internships in France (Institute Gustave-Roussy, 2011-2012), Russia (“Medical and Genetic center of N.P. Bochkov”, 2012).
Head of the Laboratory of Applied Genetics of the NCB
Head of the National Scientific Shared Laboratory of Biotechnology of the NCB
Leading Researcher at the National Scientific Shared Laboratory of Biotechnology of the NCB
Chief Researcher of the Laboratory of Proteomics and Mass Spectrometry of the NCB
Head of the Laboratory of Immunochemistry and Immunobiotechnology of the NCB
Head of the Laboratory of Molecular Biotechnology of the NCB
Head of the Laboratory of Immunology and Immunobiotechnology of the NCB branch in Almaty
Head of the Laboratory of Genetics and Biochemistry of Microorganisms of the NCB
Head of the Laboratory of Plant Genomics and Bioinformatics
The research was funded by the Science Committee of the Ministry of Science and Higher Education of the Republic of Kazakhstan (НТП BR24992881)
The research was funded by the Science Committee of the Ministry of Science and Higher Education of the Republic of Kazakhstan (НТП BR24992881)